Sebastien Powell

Sebastien Powell



1/ How was 'monkeypox' discovered? In this thread, we'll take a closer look at the original research paper, as it it raises a number of important questions. ๐Ÿงต #monkeypox

2/ The lab "receives a continuous supply of monkeys which are used for polio vaccine production and research". So these poor creatures are being shipped out to a lab in Copenhagen, to be experimented on.

3/ Upon reception, the monkeys were given antibiotics. This was given prophylactically โ€“ it would appear to prevent pneumococci 'infection'. We are not told whether this is a standard procedure.

4/ Penicillin is interesting, because one of the known 'side effects' is a rash. And it would appear that said rash can differ quite significantly in its appearance.

5/ Apparently, all polio vaccines, with the exception of one, contain penicillin. Reminder: these monkeys were being used for the the purpose of "polio vaccine production and research".

6/ This paper details the case of an individual who had a reaction to his polio vaccination, that included "generalised giant urticaria". Note also that another rash developed later on, resembling German measles. Examples included below.

7/ Back to our paper. The authors go on to state that: "Both outbreaks occurred late after arrival of the monkeys, i.e. after 51 and 62 days, respectively, and only 20 to 30 per cent of the animals developed clinical signs of disease."

8/ "The clinical manifestations were characterized by skin eruptions of a maculo-papular rash and of various pustules. The general health of the animals was not seriously affected and fatal cases were not observed."

10/ We are provided with the following pictures. It's difficult to make much out of them given that they're in black and white, but it's not entirely clear this is the same type of rash that shows up in humans โ€“ see below.

11/ Here again, we have the problem that the rash appears to differ greatly in its appearance. In some cases, it appears not all too dissimilar to shingles.

12/ We also find pictures like the following, where the rash looks quite different โ€“ but also, not all too dissimilar to certain cases of chickenpox.

13/ Interestingly, whilst looking for these images, I stumbled across 'Carrions Disease'. The site appears to be down now, so I don't know how legitimate this is โ€“ but I thought it was noteworthy.

14/ After the outbreak, the 'virus' was apparently, 'isolated'. Virologists have an interesting definition for the word 'isolate' โ€“ which usually means separation from everything else. Are you satisfied that this is what they did here?

15/ They then proceeded to try and transmit the 'virus' to other animals, starting with rabbits (?). As usual, this involved, for the most part, injecting the infected materials. The test subjects developed a "severe hemorrhagic reaction".

16/ Mice were also used, but for some reason, in this case, injections into the brain were, apparently, necessary. We are not told why.

17/ Last but not least, the experiment was carried out on 2 monkeys. These received an intradermal injection. In this case, the researchers reports that "none of these animals developed any signs of illness". Curious, huh?

18/ "However, one cynomolgus monkey ... developed a local pustule surrounded by oedema 7 days after inoculation. Attempts to re-isolate virus from the lesions were unsuccessful because of heavy contamination with molds and bacteria." Hmm...

19/ It's also interesting to note that no photographs were provided of these subjects to enable comparison with the original subject. Are we allowed to ask why?

20/ The researchers conclude by saying that they are 'puzzled' by the lengthy period of time that elapsed between the monkeys arriving, and the outbreak โ€“ and the fact that in their experiment, the lesion developed only 7 days after inoculation.

21/ Is it just me, or does it look like these monkeys are only getting sick when subjected to these experiments?

22/ Anyway, here are the questions I'd like the experts to try and answer for us. Why did this disease only manifest after these monkeys had spent time in the lab? Has his disease ever been seen in monkeys that aren't being held in captivity and experimented on?

23/ Are we supposed to completely disregard the fact that we don't know all the details of what happened to the monkeys whilst they were being held in captivity?

24/ If we were to repeat this exact experiment, using non-contaminated materials, what would we expect to see? Why was this not done?

25/ Why did the disease appear to produce different symptoms in different animals? How do we know then, that it's the same disease and not just an immune response to the injection of foreign DNA? Why did they attempt to re-infect rabbits first, and not more monkeys?

26/ How do we know the disease that we see in humans is the same seen from the very limited imagery provided of the monkeys? Why were intracerebral inoculations required in the mice? Why do the symptoms appear so different in different cases?

27/ And I have many more, but I think these make a good starting point. If you see any experts on here talking about monkeypox, these are the kind of tough questions we should be asking them. If you have any more, please do add them here so we can keep track.

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